Endocrine Abstracts

Introduction: In clinical practice guidelines for differentiated thyroid cancer (DTC) it has been proposed to perform thyroglobulin (Tg) stimulated by rTSH determination 6–12 months after initial therapy in patients with low or intermediate risk, in order to establish the absence of disease. The use of ultrasensitive Tg assays could avoid the need of stimulation to establish the absence of disease.Objectives: To evaluate the usefulness of the determ...

BackgroundThyroid nodules with indeterminate cytology represent a therapeutic challenge. The probability of malignancy had been established between 5 and 15%, but it varies among the published data. Nowadays we have molecular tests to help in therapeutic decisions, but they are not available at all centers leaving uncertainty regarding appropriate management.Objectives– To know the percentage of malignan...

Introduction: Bone metastases (BM) are rare in differentiated thyroid cancer (DTC). They determine the quality of life and survival of these patients. Our objective was to evaluate the characteristics, survival and prognostic factors of a cohort of patients with BM from CDT.Methods: Retrospective descriptive study. Patients with BM from DTC diagnosed between 1980-2021 were included. Qualitative variables are shown as n(%); quantitative variables as media...

Background: Familial non medullary thyroid carcinoma (FNMTC) is a not very well known histopatologic entity. Nowadays there are controversial publications about his aggresiveness and prognosisObjective: To know the clinical outcomes and histopathological characteristics of our patients with FNMTC and to compare them with a cohort of patients with sporadic non medullary thyroid carcinoma (CDT).Methods: We conducted a retrospective d...

Background: The indication of ablation with I131 in low-risk DTC is controversial. The exact dose needed for thyroid remnant ablation is still a matter of debate in low-risk DTC patients. However, low dose has been found to be equally effective as high dose in terms of recurrence rate in recent studies. Taking this into account the current trend is to administer lower doses, although some studies describe a higher rate of retreatment.Aims: 1. To examine ...

Background: Autonomic hyperfunctioning thyroid nodules account for approximately 5% to 10% of all thyroid nodules. Compared with non-toxic nodules, hot nodules are traditionally believed to have an exceptionally low malignancy rate, and this has led to recommendations not to perform fine-needle aspiration (FNA) on these lesions, regardless of their size. However, recent studies have questioned the presumed low risk of malignancy in hot nodules, suggesting that the incidence of...

There is a specific unit specialised in treating differentiated thyroid cancer (DTC) at the Endocrinology Department from a hospital the southwest of Spain that attends patients from two different provinces. Owing to environmental pollution, one of them has higher incidence of cancer.To evaluate the changes in the clinical presentation of DTC over time and analyse possible differences between patients from the two provinces, we designed a descriptive ret...

IntroductionBased on the evidence available back then, in 2015 we developed a provincial multicenter protocol for screening and follow up of no-index patients with SDHB and SDHC mutations.Objectives1. To evaluate the performance of the protocol designed for the follow-up of asymptomatic SDHB and C carriers. 2. To describe the penetrance of manifestations associated with hereditary PGL-FEO syndromes type 3 and...

Objective: To describe the characteristics, survival and prognostic factors of a cohort of patients with bone metastases (BM) of differentiated thyroid carcinoma (DTC).Methods: Multicenter retrospective observational study. Patients diagnosed with DTC and BM between 1980-2021 were included. A Cox regression was performed to study prognostic factors for 5- and 10-year survival. Kaplan-Meier and log-rank tests were performed for survival analysis and compa...

The role of adjuvant external beam radiotherapy (EBRT) in differenciated thyroid cancer (DTC) is controversial. It remains unknown whether EBRT in the neck following conventional treatment might improve progression-free survival (PFS) and overall survival (OS).Objective: To assess EBRT outcomes in patients with locally advanced DTC in terms of local disease progression, PFS and OS.Material and Methods: A multicentric retrospective ...